The St. Louis Rams absorbed a double blow to their offensive line with season-ending injuries to Mark Setterstrom and tackle Brandon Gorin.
Setterstrom fractured a kneecap in Saturday's exhibition game against the San Diego Chargers and will be placed on injured reserve.
Rams coach Scott Linehan on Sunday said Setterstrom will have surgery sometime this week. Last season, Setterstrom, a seventh-round pick in 2006, tore a knee ligament in the same knee in Week Three, knocking him out for the year.
"It is the same knee; it is just a completely different injury," Linehan said. "But certainly it is some tough luck to have two really tough injuries to the same leg within a year."
Gorin, meanwhile, suffered a shoulder injury in the team's preseason opener against the Tennessee Titans. The severity of the injury did not show up on an initial MRI exam.
"He has a pretty significant shoulder injury," Linehan said. "It ... is an injury that will force him out for the year."
Quarterback Marc Bulger also suffered a shoulder strain in the game, but Linehan said it is not serious.
Running back Brian Leonard, getting plenty of playing time with the lengthy holdout of starter Steven Jackson, sprained his shoulder. Linehan said that injury is not considered serious although he termed the second-year back "iffy" for next Saturday's game against the Baltimore Ravens.